Tag: intrinsically disordered regions

^{Type
post

Author
Emily Reeves

Date
August 20, 2026

Categories
Intelligent Design
Medicine
Tagged
, AlphaFold3, apoptosis, bioinformatic data, cancer, cancer cells, carboxy-terminal domain, cell death, cells, chemotherapy, chromatin, Darwin’s Black Box, DNA, DNA replication, double helix, enzymes, Freed-Hardeman University, intrinsically disordered regions, Irreducible Complexity, isoforms, Joe Deweese, mutants, proteins, replication, TOP2A, TOP2B, topoisomerases, toxic side effects}

How Irreducible Complexity Can Help with Cancer Drug Research

_{Emily Reeves
August 20, 2026

Intelligent Design, Medicine

8}

Topoisomerases are molecular machines that play a critical role in resolving DNA tangles and supercoiling generated during DNA replication. Read More ›

^{Type
post

Author
David Coppedge

Date
June 25, 2026

Categories
Evolution
Intelligent Design
Tagged
, AlphaFold, biochemistry, central dogma, condensates, conservation, Darwinian theory, devolution, disease, DNA, evolutionarily conserved, function, genetics, genome, IDR-ome, intrinsically disordered proteins, intrinsically disordered regions, Levinthal paradox, mutations, original design, PNAS, polypeptides, proteins, proteome, sequence conservation, unevolved}

Active Matter: Newfound Order in “Disordered” Proteins

_{David Coppedge
June 25, 2026

Evolution, Intelligent Design

8}

Intrinsically disordered regions of proteins may not be functionless after all. They appear to be multi-functional. Read More ›

^{Type
post

Date
March 27, 2026

Categories
Biology
Genetics
Tagged
, AlphaFold2 Multimer, binding, disorder, Drosophila melanogaster, interactome, intrinsic disorder, intrinsically disordered regions, Junhui Peng, Li Zhao, orphan genes, PLOS Computational Biology, protein-protein interactions, proteins, Rockefeller University, taxonomically restricted genes}

It Turns Out Disorder Is Functionally Important

_{Science & Culture
March 27, 2026

Biology, Genetics

1}

Li Zhao of Rockefeller University is a leading investigator on the origin and function of orphan and taxonomically restricted genes (TRGs) and proteins. Read More ›