“Junk DNA” Takes Yet More Heavy Blows
A paper has just been published in Nature which uncovers a host of new coding-independent functions for pseudogene mRNAs, including a role in tumor regulation. More exciting is that Poliseno et al. describe an entirely new regulatory function of RNA. This stands in contrast to conventional wisdom which maintains that the only function of mRNAs is encoding for proteins. According to the abstract, The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of their protein-coding function. As a model for the protein-coding-independent role of RNAs, Read More ›







































