Is “Pseudogene” a Misnomer?
The term “pseudogene” may be as inappropriate as the term “junk DNA,” according to the entry on pseudogenes in the 2010 Encyclopedia of Life Sciences, published by prestigious the academic publisher John Wiley & Sons. Written by researchers Ondrej Podlaha and Jianzhi Zhang at UC Davis and the University of Michigan, Ann Arbor, respectively, the entry includes a subjection titled “Difficulty with the Pseudogene Definition,” and it states that the discovery of multiple functional pseudogenes should negate the standard presumption that pseudogenes are functionless junk DNA: The term ‘pseudogene’ was originally coined to describe a degenerated RNA- or protein-coding sequence that is incapable of being transcribed or translated into functional RNA or protein products. The key in this definition is Read More ›