The First Rule of Adaptive Evolution: A reply to Jerry Coyne
At his blog, Why Evolution is True, Jerry Coyne, professor of evolutionary biology at the University of Chicago, has been analyzing my recent paper, “Experimental Evolution, Loss-of-Function Mutations, and ‘The First Rule of Adaptive Evolution,’” which appears in the latest issue of the Quarterly Review of Biology. Although I usually don’t respond to blog posts I will this time, both because Coyne is an eminent scientist and because he does say at least one nice thing about the paper.
First, the nice thing. About half-way through his comments Professor Coyne writes:
My overall conclusion: Behe has provided a useful survey of mutations that cause adaptation in short-term lab experiments on microbes (note that at least one of these–Rich Lenski’s study– extends over several decades).
Thanks. Much appreciated.
Next, he turns to damage control. Directly after the mild compliment, Coyne registers his main complaint about the paper: the conclusions supposedly can only be applied to laboratory evolution experiments and say little about (Darwinian) evolution in nature. “But his conclusions may be misleading when you extend them to bacterial or viral evolution in nature, and are certainly misleading if you extend them to eukaryotes (organisms with complex cells), for several reasons.” Below I deal with Coyne’s three reasons in turn.
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